To detect B cell lymphoma, the first step is to detect clonal B cells, but approximately 30% large cell lymphoma has loss light chain restriction. Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) are co-expression of CD5. CD23 and CD200 are used to distinguish MCL and CLL. CD10 is the representative marker for germinal cell. In correlation with cell size, CD38, CD39, CD43, CD81, CD95, and CD305, those help to distinguish follicular lymphoma (FL), GCB-DLBCL, Non-GCB DLBCL, and Burkitt's lymphoma (BL). CD103 is the identification marker for hairy cell leukemia (HCL), and CD62L and CD305 are help to diagnose. Marginal zone lymphoma (MZL), and lymphoplasmacytic lymphoma (LPL) need to correlate with morphology, pathology, and molecular tests.